Macduff isn't a man of many words, which means… everyone listens when he talks. We first hear Macduff as he expresses raw, honest grief at the King's murder: "O horror, horror, horror! Tongue nor heart/ Cannot conceive nor name thee! … Most sacrilegious murder hath broke ope/ The Lord's anointed temple, and stole thence/ The life o' the building!" (-79). (Apparently, even grief can't keep him from busting out elaborate metaphors to describe death.) Even more than the king's own son, Macduff appears to mourn the loss of the king, and the man.
This is Macduff's reaction to Duncan's murder in Shakespeare's tragedy. Look at the rhetorical structure of the speech. He is speaking by way of abstractions and personifications. 'confusion creating its masterpiece' refers to the sudden and shocking death of Duncan, which has created apart from all the sorrows, a genuine sense of disbelief and confusion too thereby. The metaphor is that of writing or composition. Then in the next line, he calls the concrete by way of the abstract, calling the 'murderer', 'murder'. The comparison between Duncan's body and the holy temple of the Lord reflects his loyalities for the king. Stealth of the life of the building refers to the act of murder and the the way Macduff adds a relegious heretic dimension to the murder of Duncan evokes the divine right theory of kingship.