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In this work, the effect of S 2− and O 2− anions for linked with Ru(III) were investigated and RuS 2 and RuO 2 nanoparticles loaded chitosan (Chitosan was extracted from Lobsters shells of Persian Gulf, IR. Iran) was prepared and characterized via FE-SEM, EDS and FT-IR analysis. FESEM showed the formation of spherical nanoparticles with a size ranging from 20 to 100 mm. Subsequently, the role of these new materials as curcumin drug carrier and in vitro release of curcumin in simulated body fluid (SBF) solution (pH ) were studied.